GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7267979 | 1 | rs6076345 | chr20:25381895 | FAM182A | chr20:26035250-26067552:+ | 0.19 | 3.48 | 0.000546 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6076345 | chr20:25381895 | FAM182B | chr20:25744102-25848786:- | -0.26 | -5.4 | 1.05E-7 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6076345 | chr20:25381895 | NINL | chr20:25433338-25566153:- | 0.33 | 6.9 | 1.67E-11 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6076345 | chr20:25381895 | PYGB | chr20:25228706-25278647:+ | 0.16 | 4.03 | 6.53E-5 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs2129782 | 1 | rs60779425 | chr8:89437611 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs6044112 | 1 | rs6080295 | chr20:16521334 | KIF16B | chr20:16252749-16554078:- | 0.29 | 5.34 | 1.46E-7 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs6044112 | 1 | rs6080296 | chr20:16521528 | KIF16B | chr20:16252749-16554078:- | 0.29 | 5.34 | 1.46E-7 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs6044112 | 1 | rs6080297 | chr20:16524711 | KIF16B | chr20:16252749-16554078:- | 0.29 | 5.4 | 1.07E-7 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs6044112 | 1 | rs6080301 | chr20:16535666 | KIF16B | chr20:16252749-16554078:- | 0.26 | 5.09 | 5.28E-7 | Response to taxane treatment (docetaxel) |
| THCA | cis | rs726288 | 1 | rs60823703 | chr10:81729345 | LOC219347 | chr10:81805991-81838949:- | 0.51 | 5.21 | 2.88E-7 | Rheumatoid arthritis |
| THCA | cis | rs6988636 | 1 | rs60827294 | chr8:124187842 | FAM83A | chr8:124191287-124222317:+ | -0.34 | -4.39 | 1.41E-5 | Urinary uromodulin levels |
| THCA | cis | rs7267979 | 1 | rs6083804 | chr20:25317060 | ENTPD6 | chr20:25176339-25207360:+ | 0.31 | 6.94 | 1.24E-11 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6083804 | chr20:25317060 | FAM182A | chr20:26035250-26067552:+ | 0.18 | 3.4 | 0.000741 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6083804 | chr20:25317060 | FAM182B | chr20:25744102-25848786:- | -0.27 | -5.62 | 3.21E-8 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6083804 | chr20:25317060 | NINL | chr20:25433338-25566153:- | 0.35 | 7.18 | 2.68E-12 | Liver enzyme levels (alkaline phosphatase) |